How To Write A Letter To The Fda Gras . In general, fda’s response has been in one of three categories: 9 • the second type of letter advises the notifier that the gras notice does not provide a basis that the substance is gras. GRAS Consultants GRAS Application FDA GRAS Notification from dicentra.com Between february 3, 2017 and march 31, 2017, the u.s. Following a comprehensive review of gras substances, fda conducted a rulemaking in 1972 to establish a voluntary gras affirmation petition process. Just highlight the text, delete, and fill in your own, then click the send button.